Modulation of K-Ras-Dependent Lung Tumorigenesis by MicroRNA-21
نویسندگان
چکیده
منابع مشابه
Modulation of K-Ras-dependent lung tumorigenesis by MicroRNA-21.
Lung cancer is the leading cause of cancer-related deaths in the world, and non-small-cell lung cancer (NSCLC) accounts for 80% of cases. MicroRNA-21 (miR-21) expression is increased and predicts poor survival in NSCLC. Although miR-21 function has been studied in vitro with cancer cell lines, the role of miR-21 in tumor development in vivo is unknown. We utilize transgenic mice with loss-of-fu...
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UNLABELLED Lung cancer commonly displays a number of recurrent genetic abnormalities, and about 30% of lung adenocarcinomas carry activating mutations in the Kras gene, often concomitantly with inactivation of tumor suppressor genes p16(INK4A) and p14(ARF) of the CDKN2AB locus. However, little is known regarding the function of p15INK4B translated from the same locus. To determine the frequency...
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Oncogenic K-Ras represents the most common molecular change in human lung adenocarcinomas, the major histologic subtype of non-small cell lung cancer (NSCLC). The presence of K-Ras mutation is associated with a poor prognosis, but no effective treatment strategies are available for K-Ras -mutant NSCLC. Epidemiological studies report higher lung cancer mortality rates in patients with type 2 dia...
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1. Thum T, et al. MicroRNA-21 contributes to myocardial disease by stimulating MAP kinase signaling in fibroblasts. Nature. 2008;456(7224):980–984. 2. Patrick DM, et al. Stress-dependent cardiac remodeling occurs in the absence of miR-21 in mice. J Clin Invest. 2010;120(11):3912–3916. 3. Hatley ME, et al. Modulation of K-Ras-dependent lung tumorigenesis by microRNA-21. Cancer Cell. 2010;18(3):2...
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ژورنال
عنوان ژورنال: Cancer Cell
سال: 2010
ISSN: 1535-6108
DOI: 10.1016/j.ccr.2010.08.013